Pulmonary function testing, oxygen requirements, and 6 min walk distance with Borg Dyspnoea Index (BDI) scores at baseline and end of study
| Baseline N=15 Mean (SD) | 12 weeks N=15 Mean (SD) | p Value* | |
|---|---|---|---|
| Pulmonary function | |||
| FVC, % predicted | 62 (21) | 63 (18) | 0.687 |
| FEV1, % predicted | 62 (17) | 64 (16) | 0.215 |
| FEV1/FVC | 77 (11) | 80 (12) | 0.134 |
| TLC, % predicted | |||
| All patients | 70 (15) | – | |
| Patients without CPFE, n=12 | 67 (16) | – | |
| DLCO, % predicted† | 24 (13) | 22 (11) | 0.206† |
| FVC%/DLCO%† | 2.5 (2.4) | 3.0 (1.6) | 0.625† |
| Oxygen flow (L/min) | 3.9 (1.9) | 3.9 (2.1) | >0.999 |
| 6 min walk: | |||
| 6 min walk distance (m) | 171 (93) | 230 (114) | <0.001 |
| Room air % saturation | 83 (7) | 80 (10) | 0.078 |
| 10 L face mask, % saturation† | 98 (3) | 99 (4) | 0.372† |
| 10 L face mask, % saturation nadir | 85 (9) | 82 (10) | 0.084 |
| BDI score | 13.7 (2.3) | 13.1 (2.6) | 0.203 |
*Paired t test p value presented, except when Wilcoxon signed rank indicated.
†Data are non-normally distributed; median (IQR) and Wilcoxon signed rank p value presented.
CPFE, combined pulmonary fibrosis emphysema; DLCO, diffusing capacity for carbon monoxide; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; TLC, total lung capacity.