Demographic characteristics of individuals with active tuberculosis compared with those with no mycobacterial interspersed repetitive units containing variable numbers of tandem repeats (MIRU-VNTR) value and when no mycobacterial lineage could be assigned
| Variable | Subjects included in study (n=1070) | Subjects with no MIRU available (n=242) | p Value* | Subjects with no lineage assigned (n=312) | p Value† |
|---|---|---|---|---|---|
| Age | |||||
| Median (IQR) | 34.8 (25.0–49.7) | 36.2 (24.0–49.6) | 0.11 | 32 (25.3–52.2) | 0.42 |
| Age categories | |||||
| Under 16 | 36 (3.4%) | 12 (5.0%) | 18 (5.8%) | ||
| 16–25 | 273 (25.5%) | 54 (22.3%) | 66 (21.2%) | ||
| 26–35 | 261 (24.4%) | 53 (21.9%) | 98 (31.4%) | ||
| 36–45 | 194 (18.1%) | 36 (14.9%) | 34 (10.9%) | ||
| 46–55 | 96 (9.0%) | 21 (8.7%) | 32 (10.3%) | ||
| over 55 | 210 (19.6%) | 66 (27.3%) | 64 (20.5%) | ||
| Gender | |||||
| Men | 579 (54.1%) | 145 (59.9%) | 0.12 | 159 (51.0%) | 0.33 |
| Ethnicity | |||||
| White | 148 (13.8%) | 30 (12.4%) | 0.50 | 24 (7.7%) | 0.024 |
| Indian subcontinent | 577 (53.9%) | 125 (51.7%) | 185 (59.3%) | ||
| Afro-Caribbean | 278 (26.0%) | 72 (29.8%) | 89 (28.5%) | ||
| Oriental/other Asia | 23 (2.2%) | 8 (3.3%) | 3 (1.0%) | ||
| Other | 44 (4.1%) | 7 (2.9%) | 11 (3.5%) | ||
| Place of birth | |||||
| Foreign born | 752 (70.3%) | 181 (74.8%) | 0.16 | 248 (79.5%) | 0.001‡ |
| Time since entry to the UK (years) | |||||
| Median (IQR) | 5 (2–21)§ | 6 (3–20) | 0.54 | 6 (3–18) | 0.76 |
| <1 | 24 (3.4%) | 8 (4.9%) | 11 (4.8%) | ||
| 1–5 | 338 (48.0%) | 72 (44.2%) | 95 (41.1%) | ||
| 6–10 | 95 (13.5%) | 24 (14.7%) | 47 (20.4%) | ||
| >10 | 247 (35.1%) | 59 (36.2%) | 78 (33.8%) | ||
| HIV status | |||||
| Negative | 70 (84.3%)¶ | 13 (86.7%) | 0.82 | 23 (95.8%) | 0.14 |
| Previous TB | |||||
| No | 1030 (96.3%) | 228 (94.2%) | 0.14 | 299 (95.8%) | 0.72 |
| Type of disease | |||||
| Pulmonary only | 557 (52.1%) | 115 (47.5%) | 0.23 | 155 (49.7%) | 0.48 |
| Pulmonary and extrapulmonary | 118 (11.0%) | 37 (15.3%) | 0.08 | 40 (12.8%) | 0.42 |
| Extrapulmonary only | 395 (36.9%) | 90 (37.2%) | 0.94 | 117 (37.5%) | 0.89 |
| Extrathoracic only | 318 (29.7%) | 73 (30.2) | 0.88 | 96 (30.8) | 0.73 |
| Lymph node only | 204 (19.1%) | 44 (18.2) | 0.79 | 63 (20.2) | 0.68 |
| Smear result | |||||
| Positive | 545 (50.9%) | 108 (44.6%) | 150 (48.1%) | 0.40 | |
| Drug sensitivity** | |||||
| Fully sensitive | 976 (95.2%) | 117 (88.0%) | 0.007 | 288 (96.6%) | 0.43 |
| Mono-drug resistant | 37 (3.6%) | 12 (9.0%) | 9 (3.0%) | ||
| Multi-drug resistant | 12 (1.2%) | 4 (3.0%) | 1 (0.3%) | ||
*p Value for subjects with no MIRU-VNTR available versus subjects included in study; continuous variables compared using the Mann–Whitney U test and categorical variables (percentages/proportions) using Fisher's exact test.
†p Value for subjects with no lineage assigned versus subjects included in study; continuous variables compared using the Mann–Whitney U test and categorical variables (percentages/proportions) using Fisher's exact test.
‡Subjects with no lineage assigned (compared with those included in the study) were significantly more likely to be foreign-born individuals (p=0.001).
§Data available for 704 individuals.
¶Data available for 83 individuals.
**Data available for 1025 individuals.