Adjusted ORs in multivariate logistic regression models for factors associated with the development of severe exacerbations and any exacerbations in the whole asthma cohort and severe asthma group
| Factor | OR | 95% CI | p Value | Comments |
|---|---|---|---|---|
| Severe exacerbations | ||||
| Juniper ACQ >1.36 (median) | 3.61 | 1.7 to 7.65 | 0.001 | Adjusted for age, gender, smoking and atopy |
| Sputum eosinophils ≥3% | 3.27 | 1.13 to 9.42 | 0.028 | As above |
| BMI >25 | 2.9 | 1.3 to 6.5 | 0.01 | As above |
| SGRQ >34.6 (median) | 2.22 | 1.03 to 4.8 | 0.042 | As above |
| Whole study group | ||||
| Smoking history | 3.69 | 1.66 to 8.21 | 0.001 | Adjusted for age, gender and atopy |
| SGRQ >34.6 (median) | 3.09 | 1.41 to 6.76 | 0.005 | Adjusted for age, gender, smoking and atopy |
| Juniper ACQ >1.36 (median) | 3.07 | 1.49 to 6.29 | 0.002 | Adjusted for age, gender, smoking and atopy |
| Atopy | 2.06 | 1.01 to 4.19 | 0.047 | Adjusted for age, gender and smoking |
| Reversibility ≥12% | 2.04 | 1.0 to 4.14 | 0.049 | Adjusted for age, gender, smoking and atopy |
| Sputum eosinophils ≥3% | 2.39 | 0.89 to 6.37 | 0.081 | As above |
| FEV1 ≤80% | 1.93 | 0.95 to 3.93 | 0.071 | As above |
| Severe asthma | ||||
| Smoking history | 9.14 | 2.47 to 33.87 | 0.001 | Adjusted for age, gender and atopy |
| Female gender | 4.47 | 1.55 to 12.84 | 0.005 | Adjusted for age, smoking and atopy |
| Age <65 years | 4.28 | 1.03 to 17.82 | 0.046 | Adjusted for gender, smoking and atopy |
| Juniper ACQ >2.14 (median) | 3.58 | 1.14 to 11.29 | 0.029 | Adjusted for age, gender, smoking and atopy |
| BMI >30 | 0.28 | 0.09 to 0.87 | 0.028 | As above |
| SGRQ >44.1 (median) | 2.465 | 0.85 to 7.17 | 0.098 | As above |
There were no statistically significant factors found in the mild to moderate asthma group.
ACQ, Asthma Control Questionnaire; BMI, body mass index; FEV1, forced expiratory volume in 1 s; SGRQ, St George's Respiratory Questionnaire.