Table 2

Allele frequency in control and ILD patient cohorts

	G allele	T allele	OR* (95% CI)	p Value
Control (n=416)	0.90	0.10
IPF (n=110)	0.64	0.36	4.90 (3.42 to 7.03)	2.04×10⁻¹⁷
SSc (n=440)	0.88	0.12	1.16 (0.85 to 1.57)	0.36
No ILD (n=211)	0.89	0.11	1.06 (0.73 to 1.56)	0.76
SSc-ILD (n=229)	0.88	0.12	1.24 (0.86 to 1.79)	0.24
ATA +ve (n=110)	0.88	0.12	1.25 (0.79 to 1.98)	0.35
ACA +ve (n=109)	0.88	0.12	1.26 (0.79 to 1.99)	0.33
Non-ATA/non-ACA (n=208)	0.90	0.10	1.03 (0.69 to 1.51)	0.89
Sarcoidosis (n=180)	0.89	0.11	1.11 (0.75 to 1.65)	0.60
Stage 0–III (n=98)	0.87	0.13	1.30 (0.82 to 2.08)	0.29
Stage IV (n=73)	0.91	0.09	0.90 (0.49 to 1.64)	0.71

Data are presented as allele frequency; p value is compared with the control cohort.
*Of the T allele.
ACA, anti-centromere antibody; ATA, anti-DNA topoisomerase 1 antibody; ILD, interstitial lung disease; IPF, idiopathic pulmonary fibrosis; SSc, systemic sclerosis.