Healthy controls (n=21) | COPD (P) (n=27) | COPD (S) (n=32) | |
---|---|---|---|
Age (years) | 66.1 (1.0) | 66.9 (1.7) | 68.9 (1.7) |
Gender (M:F) | 10:11 | 14:13 | 19:13 |
BMI (kg/m2) | 26.8 (0.6) | 25.5 (1.0) | 26.6 (0.8) |
FFMI (kg/m2) | 17.5 (0.3) | 16.9 (0.4) | 17.6 (0.4) |
Subjects with muscle wastage (n) | 0 | 7 | 6 |
Smoking pack years | 14.4 (5.1)* ** | 48.1 (5.6) | 46.9 (7.9) |
Physical activity score | 10.3 (1.2)* ** | 6.1 (0.3) | 6.8 (1.1) |
FEV1 (litres) | 2.5 (0.1)* ** | 1.1 (0.0) | 1.12 (0.0) |
FEV1 (% predicted) | 105.0 (4.7)* ** | 45.8 (3.2) | 47.7 (3.3) |
FEV1/FVC (%) | 71.8 (1.4)* ** | 41.2 (2.1) | 39.42.4) |
Thigh lean mass (g) | 4190 (189) | 3700 (191) | 3829 (153) |
Isometric peak torque (Nm) | 135.8 (9.5)* ** | 109.3 (9.8) | 105.9 (7.4) |
Isokinetic peak torque (Nm) | 98.0 (7.9)** | 75.8 (6.9) | 79.9 (6.0) |
Isokinetic peak work (J) | 373.8 (33.0)** | 284.5 (28.2) | 307.5 (25.2) |
Cycle peak VO2 (ml/kg/min) | 22.8 (1.4)* ** | 14.7 (0.9) | 14.4 (0.6) |
Cycle peak workload (W) | 119.9 (8.7)* ** | 51.1 (4.7) | 48.9 (3.8) |
Subjects who provided a minimum of a baseline and 24 h muscle biopsy were included in the analysis (see online supplementary figure 1S). Figures refer to mean (SEM).
Details of the questionnaire used to measure physical activity score is given in the online supplementary materials and methods.
*p≤0.05; HC versus COPD (S); **p≤0.05; HC versus COPD (P).
BMI, body mass index; COPD (P), patients with COPD allocated placebo; COPD (S), patients with COPD allocated supplements; FFMI, fat-free mass index; HC, healthy control.