Overview of OSCILLATE and OSCAR
| Intervention | OSCILLATE | OSCAR |
|---|---|---|
| Oscillator | SensorMedics 3100B oscillator (CareFusion) | Novalung R100 (Metran) |
| Distribution | Extensively used in North America and Europe | Extensively used in Japan, not used in Europe or North America |
| I:E ratio | Usually used with 1:2 I:E Which may lead to lower pressures in alveoli than measured on oscillator | Fixed I:E 1:1 |
| Modes | HFOV mode only—transition to conventional ventilation requires swapping ventilators | HFOV, PCV, VCV, PSV, CPAP |
| Centres | 39—mainly North America (35) | 29 UK |
| Previously used HFOV | 20 no HFOV experience, 6 limited | |
| Enrolled if PaO2/FiO2 ≤200 mm Hg on a FIO2≥0.5 irrespective of PEEP Randomised if PaO2/FiO2≤200 mm Hg after 30 min on standard settings (FIO2≥0.6, PEEP of ≥10 cm H2O and tidal volume 6 ml/kg) | Randomised if PaO2/FiO2≤200 mm Hg on a PEEP of ≥5 cm H2O | |
| Recruitment manoeuvres | Mandated in protocol | Maybe used not mandated |
| Cross-over to HFOV | Permitted | Not permitted |
| Mortality | 47% HFOV vs 35% control In hospital | 41.7% HFOV vs 41.1% conventional ventilation at 30 days |
HFOV, high-frequency oscillatory ventilation.