Table 5

Treatment comparisons versus placebo for change from baseline in mean rescue medication usage at week 6

Rescue medication usage (daily no. of puffs averaged over each week)	Placebo	PH-797804 dose
	Placebo	0.5 mg	3 mg	6 mg	10 mg
N (baseline)	40	16	43	63	42
Baseline, mean (SD)	3.40 (2.84)	2.03 (2.30)	3.50 (2.47)	3.42 (4.81)	2.55 (2.34)
N (week 6)	38	15	40	54	38
Adjusted mean change (puffs per day)	0.309	0.025	−0.165	−0.351	0.115
SE of the mean	0.249	0.395	0.241	0.204	0.246
95% CI	(−0.183 to 0.801)	(−0.754 to 0.805)	(−0.641 to 0.311)	(−0.753 to 0.052)	(−0.372 to 0.601)
Difference between means*		−0.283	−0.473	−0.659	−0.194
SE of difference*		0.467	0.346	0.322	0.351
95% one-sided lower limit for difference*		0.490	0.100	−0.127	0.386
p Value (difference between means)*		0.273	0.087	0.021	0.291

*Comparisons are between each dose of PH-797804 and placebo using the full analysis set, which included all patients who were randomised and had a valid FEV₁ measurement during the double-blind treatment phase.
FEV₁, forced expiratory volume in 1 s;