Table 2

Trough FEV₁: treatment comparisons versus placebo at week 6

FEV₁ (ml)	Placebo	PH-797804 dose
FEV₁ (ml)	Placebo	0.5 mg	3 mg	6 mg	10 mg
N	42	18	44	65	42
Raw mean change from baseline	−43	18	38	37	4
SD of change from baseline	160	128	235	192	201
Estimated change from baseline*	−52	7	34	41	15
95% CrI for change from baseline	(−110 to 6)	(−62 to 82)	(−17 to 86)	(−2 to 85)	(−42 to 73)
Estimated difference from placebo		59	85	92	66
95% CrI of effect over placebo		(−23 to 149)	(8 to 164)	(18 to 166)	(−17 to 151)
Probability of effect >0 ml†		0.927	0.984	0.992	0.945
Probability of effect >75 ml ‡		0.331	0.601	0.673	0.408

*The estimates are derived from the fitted statistical Bayesian model (normal dynamic linear model).
†A value>0.95 indicates statistical significance.
‡A value>0.5 indicates that the magnitude of effect is of interest.
CrI, credible interval (ie, Bayesian CI); FEV₁, forced expiratory volume in 1 s.