Treatment differences on Day 21 Least squares means (95% Confidence interval) | |||
---|---|---|---|
QVA149–Placebo | QVA149–Tiotropium | Tiotropium–Placebo | |
Exercise endurance time (seconds) | 59.5 (17.7, 101.3)** | –6.7 (–47.5, 34.0) | 66.3 (24.8, 107.7)** |
IC at isotime (L)‡ | 0.32 (0.23, 0.40)*** | 0.14(0.05, 0.22)** | 0.18(0.10.0.27)*** |
Trough IC (L) | 0.19 (0.09, 0.29)*** | 0.15 (0.06, 0.25)** | 0.04 (–0.06, 0.13) |
Trough FEV1 (L) | 0.20 (0.15, 0.26)*** | 0.10 (0.05, 0.15)*** | 0.10 (0.05, 0.15)*** |
Trough FVC (L) | 0.28 (0.19, 0.37)*** | 0.11 (0.02, 0.20)* | 0.17 (0.08, 0.27)*** |
↵***p<0.001; **p<0.01; *p<0.05; ‡Isotime is the latest matching point during exercise at which for all periods for a patient there is an IC assessment; IC: inspiratory capacity; FEV1: forced expiratory volume in 1 sec; FVC: forced vital capacity.