Total number of patients (n) | LSM treatment difference (SE) in mL | |||
---|---|---|---|---|
Glycopyrronium–placebo | Tiotropium–placebo | Glycopyrronium–tiotropium | ||
Day 1 | ||||
FEV1 AUC0–4h | 1165 | 190 (9)* | 140 (9)* | 50 (8)* |
FEV1 AUC0–12h | 164 | 180 (25)* | 130 (25)* | 50 (20)† |
Week 26 | ||||
FEV1 AUC0–12h | 152 | 210 (41)* | 210 (41)* | –10 (33)NS |
FEV1 AUC12–24h | 152 | 200 (43)* | 210 (42)* | –10 (33)NS |
FEV1 AUC0–24h | 152 | 200 (41)* | 210 (40)* | –10 (32)NS |
↵*p<0.001; † p<0.05; NS=not significant.