Table 1

CF therapeutics evaluated by the TDN and approved by the FDA

MedicationTherapeutic areaFDA approval
PancrelipasePancreatic enzyme replacement therapy
 (Creon, Zenpep)2009
 (Pancreaze)2010
 (Pertzye)2012
 (Ultresa)2012
Aztreonam lysate for inhalation (Cayston)Inhaled antibiotic2010
Ivacaftor (Kalydeco)CFTR potentiator2012

  • CF, cystic fibrosis; TDN, Therapeutics Development Network.