Odds ratios for lung cancer (N=49493, 11,888 cases and 37,605 controls)
| Odds ratio (OR) 95% CI | Adjusted OR* 95% CI | ||||
|---|---|---|---|---|---|
| Smoking | Never | 1.00 | 1.00 | ||
| Highest ever recorded | Trivial/light | 6.00 | 5.42–6.65 | 5.88 | 5.31–6.52 |
| prior to index date | Moderate | 9.67 | 8.87–10.54 | 9.33 | 8.56–10.18 |
| Heavy/very heavy | 15.58 | 14.35–16.91 | 14.88 | 13.71–16.16 | |
| Smoker but unknown quantity | 3.48 | 3.20–3.78 | 3.44 | 3.17–3.74 | |
| Missing smoking status | 1.79 | 1.59–2.02 | 1.76 | 1.56–1.99 | |
| COPD | No diagnosis prior to index date | 1.00 | 1.00 | ||
| Interval between | within 6 months | 11.47 | 9.38–14.02 | 6.81 | 5.49–8.45 |
| first diagnosis & | 6 months up to 1 year | 4.76 | 3.85–5.89 | 2.52 | 2.00–3.19 |
| index date | 1 year up to 5 years | 4.34 | 3.95–4.78 | 2.48 | 2.24–2.75 |
| 5 years up to 10 years | 4.83 | 4.29–5.44 | 2.68 | 2.36–3.05 | |
| 10 years or more | 3.74 | 3.25–4.31 | 2.18 | 1.87–2.54 | |
| Pneumonia | No diagnosis prior to index date | 1.00 | 1.00 | ||
| Interval between | within 6 months | 14.91 | 11.75–18.94 | 13.33 | 10.24–17.35 |
| first diagnosis & | 6 months up to 1 year | 3.37 | 2.42–4.70 | 2.89 | 1.99–4.18 |
| index date | 1 year up to 5 years | 2.59 | 2.22–3.02 | 2.16 | 1.82–2.57 |
| 5 years up to 10 years | 2.52 | 2.04–3.10 | 2.11 | 1.66–2.67 | |
| 10 years or more | 1.68 | 1.35–2.09 | 1.46 | 1.15–1.86 | |
OR, Odds ratio. CI, confidence interval. COPD, Chronic obstructive pulmonary disease.
↵* Adjusted for smoking & Townsend quintile (a measure of socioeconomic status).