Entire cohort,* n=28 | Complete fissure,* n=13 | Incomplete fissure,* n=15 | Difference in CF vs ICF p value† | |
ΔFEV1 |
|
| 0.717 | |
ΔFVC |
|
| 0.311 | |
ΔRV/TLC |
|
|
| 0.191 |
ΔRV |
|
|
| 0.215 |
ΔTLC |
|
|
| 0.422 |
ΔMRCD |
|
| 0.407 | |
Δ6MWT |
|
| 0.781 | |
ΔSGRQ |
|
| 0.427 |
↵* Data normally distributed, presented as mean ± SD.
↵† Comparison of CFs and ICFs via Student t test; significance defined as p≤0.008 when corrected for multiple comparison.
↵‡ Comparison by paired t test.
↵§ Responder definitions: ΔFEV1 and FVC ≥ +12%; ΔMRCD ≤−1 U; Δ6MWT ≥ 54 m; ΔSGRQ ≤−4 U.
6MWT, 6 min walk test; CF, complete fissure; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; ICF, incomplete fissure. MRCD, Medical Research Council Dyspnoea; RV, residual volume; SGRQ, St George's Respiratory Questionnaire; TLC, total lung capacity.