Frequency of ≥5%, ≥10% and ≥15% decline in FVC at 12 months
| Method of calculation | 12-month FVC decline | ||
| ≥5% | ≥10% | ≥15% | |
| Whole cohort (n=142) | |||
| Relative change | 70 (49.3) | 43 (30.3) | 30 (21.1) |
| Absolute change | 52 (36.6) | 26 (18.3) | 11 (7.7) |
| p Value for difference between methods | <0.001 | <0.001 | <0.001 |
| Excluding patients with severe disease (n=108)* | |||
| Relative change | 58 (53.7) | 36 (33.3) | 25 (23.2) |
| Absolute change | 46 (42.6) | 22 (20.4) | 7 (6.5) |
| p Value for difference between methods | <0.001 | <0.001 | <0.001 |
Data presented as number of patients (% of patients) meeting the stated threshold.
↵* Patients were excluded from this analysis if baseline FVC <50% or DLCO <35%.
DLCO, diffusion capacity for carbon monoxide; FVC, forced vital capacity.