Demographics of the population and summary data (n=143 children)
| Initial scan (t−1) (n=301) | Subsequent scan (t) (n=301) | |
| Demographics | ||
| Age (years) | 2.00 (0.97–3.24) | 3.01 (1.98–4.25) |
| Sex (% female) | 51% (73/143) | |
| Severe CFTR genotype (%)* | 90% (114/126) | |
| Pancreatic sufficiency (%) | 16% (23/143) | |
| Respiratory symptoms (%) | 20% (59/301) | 22% (63/291) |
| Pulmonary inflammation | ||
| Inflammatory response score | −0.18 (−1.03–0.84) | −0.05 (−1.04–0.87) |
| Total cell count (×103/ml) | 293 (13–490) | 300 (176–476) |
| Neutrophil count (×103/ml) | 46 (17–139) | 59 (16–160) |
| Per cent neutrophils (%) | 19% (9–37) | 22% (9–42) |
| IL-8 level (pg/ml) | 740 (220–2040) | 1050 (340–2260) |
| Detectable neutrophil elastase | 29% (86/298) | 31% (94/300) |
| Pulmonary infection | ||
| Uninfected (%) | 33% (99/298) | 30% (91/300) |
| Mixed oral flora only (%) | 30% (90/298) | 25% (76/300) |
| Infected (%)† | 37% (109/298) | 44% (133/300) |
| Bacterial infection | 32% (95/298)‡ | 38% (115/300)§ |
| Fungal infection | 10% (30/298)¶ | 15% (46/300)** |
| Structural lung disease | ||
| Detectable bronchiectasis (%) | 44% (133/301) | 62% (187/301) |
| Extent of bronchiectasis | 0 (0–2) | 1 (0–3) |
| Detectable air trapping (%) | 73% (220/301) | 74% (222/301) |
| Extent of air trapping | 2 (0–5) | 2 (0–6) |
Data represented as median (25th–75th percentile) or percentage (absolute numbers) as appropriate.
↵* Complete data for CFTR genotype are not available for all subjects as both genes have not been identified in all children and some CFTR mutations have unknown effects on CFTR function.
↵† Some infections included both bacterial and fungal organisms.
↵‡ Including 26 infections with Pseudomonas aeruginosa, 26 infections with Staphylococcus aureus, 21 infections with Haemophilus influenzae, eight infections with Streptococcus pneumoniae and 33 infections with other bacteria.
↵§ Including 30 infections with P aeruginosa, 40 infections with S aureus, 32 infections with H influenzae, 11 infections with S pneumoniae and 39 infections with other bacteria.
↵¶ Including 19 infections with Aspergillus species, seven infections with Candida and seven infections with other fungi.
↵** Including 32 infections with Aspergillus species, 12 infections with Candida and 10 infections with other fungi.
CFTR, cystic fibrosis transmembrane regulator; IL-8, interleukin 8.