Table 3

Relationship between decline in FVC at 12 months and transplant-free survival at 2 years

Method of calculation12-month FVC decline of ≥5%12-month FVC decline of ≥10%12-month FVC decline of ≥15%
OR (95% CI)Adjusted OR* (95% CI)OR (95% CI)Adjusted OR* (95% CI)OR (95% CI)Adjusted OR* (95% CI)
Whole cohort (n=142)
 Relative change2.09 (0.96 to 4.55)2.76 (0.98 to 7.80)2.47 (1.10 to 5.53)3.39 (1.14 to 10.07)3.55 (1.45 to 8.71)4.31 (1.30 to 14.29)
 Absolute change2.04 (0.93 to 4.48)5.21 (1.64 to 16.60)3.10 (1.22 to 7.89)4.52 (1.27 to 16.12)3.00 (0.85 to 10.53)1.75 (0.33 to 9.40)
Excluding patients with severe disease (n=108)†
 Relative change2.41 (0.87 to 6.66)2.58 (0.77 to 8.60)2.40 (0.90 to 6.43)2.51 (0.75 to 8.33)4.32 (1.50 to 12.45)4.71 (1.26 to 17.66)
 Absolute change2.48 (0.93 to 6.64)4.29 (1.19 to 15.41)4.02 (1.36 to 11.86)4.89 (1.18 to 20.23)2.53 (0.52 to 12.29)1.15 (0.14 to 9.74)

  • ↵* Adjustment for gender and baseline age, oxygen use, FVC and DLCO.

  • ↵† Patients were excluded from this analysis if baseline FVC <50% or DLCO <35%.

  • DLCO, diffusion capacity for carbon monoxide; FVC, forced vital capacity.