Subject demographics and baseline characteristics for the two data sets
| Study 1 (mild to moderate) | Study 2 (severe) | p Value | |
| Number of subjects | 132 | 159 | – |
| Female sex (%) | 70 (53) | 90 (57) | 0.542† |
| Age, mean years (range) | 38.9 (18–64) | 52.5 (27–81) | <0.001 |
| Height, cm | 170±10 | 169±10 | 0.312 |
| Patients with history of smoking* (%) | 16 (12) | 45 (28) | 0.001† |
| Patients taking inhaled corticosteroids at entry (%) | 109 (83) | 159 (100) | 0.002† |
| Inhaled corticosteroid dose, median μg/day (range) | 800 (100–3200) | 1000 (1000–3000) | <0.001‡ |
| Baseline FEV1, litres | 2.67±0.88 | 1.86±0.59 | <0.001 |
| Baseline FEV1, percentage of predicted | 80.1±17.9 | 64.8±13.6 | <0.001 |
| Baseline morning PEF, l/min | 420±101 | 283±116 | <0.001 |
| Baseline morning PEF, percentage of predicted | 77.3±15.4 | 53.6±18.0 | <0.001 |
| Baseline Asthma Control Score | – | 2.94±0.73 | – |
| Baseline Asthma Quality of Life Score | – | 4.17±1.11 | – |
Mean±SD and p values for t tests comparing the mild to moderate and severe asthma groups are shown unless indicated otherwise.
↵* All patients who had smoked during the year before screening or who had a smoking history of >5 (mild to moderate asthma) or 10 (severe asthma) pack years were excluded from the original studies.
↵† p Value given for the Pearson χ2 test.
↵‡ p Value given for t test on ranks (Mann–Whitney).