dummy dAb | p55-dAb | |||
After instillation | End | After instillation | End | |
1-hit model | ||||
Elastance (ml/cmH2O/kg) | 0.91±0.13 | 1.07±0.21* | 0.91±0.16 | 0.93±0.18 |
PO2 (mm Hg) | 444±72 | 287±180* | 450±26 | 415±86 |
BALF protein (mg/ml) | 2.9±1.7 | 1.4±0.4† | ||
2-hit model | ||||
Elastance (ml/cmH2O/kg) | 0.94±0.11 | 1.08±0.2* | 0.88±0.08 | 0.9±0.11 |
PO2 (mm Hg) | 486±21 | 305±168* | 497±16 | 434±114 |
BALF protein (mg/ml) | 3.0±1.6 | 2.1±1.5 | ||
Lung neutrophils | 2.30±0.57×106 | 1.25±0.34×106† | ||
BALF neutrophils/ml | 1.92±1.69×105 | 0.47±0.41×105† | ||
ALveolar macrophage ICAM-1 (MFI) | 80±20 | 56±13† |