Association between annual average exposure to air pollution at the birth address and doctor-diagnosed asthma in the first 8 years of life stratified by different genotypes of TLR4 single nucleotide polymorphisms (SNPs)
| TLR4 SNP | Adjusted OR* (95% CI) | p Values interaction† | ||
| rs2770150 | TT | TC | CC | TC/CC |
| PM2.5 | 0.95 (0.60 to 1.49) | 2.01 (1.13 to 3.57)* | 0.92 (0.27 to 3.11) | 0.04/0.97 |
| Soot | 0.93 (0.62 to 1.40) | 1.86 (1.10 to 3.13)* | 0.67 (0.30 to 1.50) | 0.04/0.46 |
| NO2 | 0.87 (0.59 to 1.27) | 1.79 (1.11 to 2.87)* | 0.75 (0.31 to 1.84) | 0.01/0.76 |
| rs10759931 | GG | GA | AA | GA / AA |
| PM2.5 | 2.61 (1.40 to 4.88)** | 1.17 (0.68 to 2.04) | 0.63 (0.29 to 1.35) | 0.06/0.005 |
| Soot | 2.40 (1.44 to 4.02)*** | 1.04 (0.64 to 1.69) | 0.63 (0.30 to 1.31) | 0.02/0.004 |
| NO2 | 2.01 (1.27 to 3.20)** | 1.09 (0.71 to 1.69) | 0.59 (0.30 to 1.18) | 0.06/0.004 |
| rs6478317 | AA | AG | GG | AG/GG |
| PM2.5 | 1.05 (0.65 to 1.68) | 1.61 (0.84 to 3.09) | 2.24 (1.18 to 4.26)* | 0.29/0.06 |
| Soot | 0.96 (0.62 to 1.50) | 1.55 (0.87 to 2.75) | 2.14 (1.23 to 3.74)** | 0.20/0.03 |
| NO2 | 1.06 (0.70 to 1.59) | 1.26 (0.75 to 2.12) | 2.05 (1.21 to 3.49)** | 0.59/0.04 |
| rs10759932 | TT | CT or CC | ||
| PM2.5 | 1.23 (0.82 to 1.85) | 2.90 (1.22 to 6.91)* | 0.07 | |
| Soot | 1.24 (0.84 to 1.82) | 2.28 (1.13 to 4.63)* | 0.13 | |
| NO2 | 1.18 (0.82 to 1.69) | 1.79 (1.06 to 3.02)* | 0.17 | |
| rs1927911 | CC | CT | TT | CT/TT |
| PM2.5 | 1.02 (0.65 to 1.59) | 1.60 (0.80 to 3.20) | 4.43 (1.68 to 11.73)** | 0.29/0.007 |
| Soot | 0.98 (0.65 to 1.48) | 1.54 (0.83 to 2.86) | 3.24 (1.45 to 7.21)** | 0.23/0.009 |
| NO2 | 1.04 (0.71 to 1.51) | 1.28 (0.73 to 2.24) | 2.54 (1.30 to 4.96)** | 0.54/0.02 |
| rs11536878 | CC | CA or AA | ||
| PM2.5 | 1.28 (0.87 to 1.87) | 1.60 (0.70 to 3.67) | 0.63 | |
| Soot | 1.18 (0.84 to 1.67) | 1.56 (0.77 to 3.15) | 0.48 | |
| NO2 | 1.20 (0.88 to 1.64) | 1.28 (0.66 to 2.49) | 0.86 | |
| rs4986790 | AA | AG or GG | ||
| PM2.5 | 1.36 (0.90 to 2.06) | 1.06 (0.56 to 2.02) | 0.53 | |
| Soot | 1.25 (0.84 to 1.85) | 1.19 (0.68 to 2.09) | 0.89 | |
| NO2 | 1.18 (0.82 to 1.69) | 1.17 (0.67 to 2.01) | 0.97 | |
| rs4986791 | CC | CT or TT | ||
| PM2.5 | 1.37 (0.90 to 2.08) | 1.10 (0.53 to 1.26) | 0.61 | |
| Soot | 1.28 (0.87 to 1.89) | 1.24 (0.65 to 2.33) | 0.92 | |
| NO2 | 1.22 (0.85 to 1.74) | 1.14 (0.61 to 2.13) | 0.86 | |
| rs11536889 | GG | GC or CC | ||
| PM2.5 | 1.40 (0.88 to 2.24) | 1.27 (0.74 to 2.20) | 0.79 | |
| Soot | 1.35 (0.88 to 2.06) | 1.16 (0.71 to 1.89) | 0.64 | |
| NO2 | 1.26 (0.85 to 1.87) | 1.17 (0.74 to 1.84) | 0.79 | |
Bold values are significant: *p<0.05; **p<0.01; ***p<0.001.
↵* ORs represent the factor by which the odds of asthma changes with an interquartile range increase in annual average pollutant concentration at birth address adjusted for confounders within each genotype group.
↵† p Values of interaction represent p values of the differences in ORs between the specific genotype group and the common allele homozygote group.