Comparison of pulmonary function in extremely preterm and control children
| Group | Extremely preterm (EP) n=38 | Control n=38 | Mean difference (95% CI) (EP–control) | p Value |
| FEV1 Z-score* | −1.64 (1.32) | 0.10 (0.90) | −1.74 (−2.25 to −1.23) | <0.0001 |
| FEF25–75 Z-score* | −2.10 (1.3) | −0.51 (1.1) | −1.59 (−2.12 to −1.00) | <0.0001 |
| FVC Z-score* | −0.89 (1.1) | 0.25 (0.97) | −1.14 (−1.6 to −0.67) | <0.0001 |
| KCO Z-score† | −2.15 (1.11) | −1.42 (1.15) | −0.73 (−1.31 to −0.17) | 0.01 |
| DLCO Z-score† | −1.1 (1.0) | −0.16 (1.0) | −0.94 (−1.41 to −0.43) | <0.001 |
| RV Z-score† | 1.31 (1.10) | 0.73 (0.83) | 0.58 (0.10 to 1.10) | 0.02 |
| TLC Z-score† | 0.23 (0.44) | 0.41 (0.52) | −0.18 (−0.43 to 0.06) | 0.14 |
| RV/TLC Z-score‡ | 1.13 (0.94) | 0.39 (0.83) | 0.74 (0.29 to 1.19) | 0.001 |
Data presented as mean (SD).
↵* Stanojevic et al (2008).28
↵† Rosenthal et al (1993).27
↵‡ Rosenthal (2008).26
DLCO, diffusing capacity for carbon monoxide; FEF25–75, forced midexpiratory flow rate; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity KCO, diffusing capacity for carbon monoxide corrected for alveolar volume; RV, residual volume; TLC, total lung capacity.