Comparison of week 4 per protocol overnight polysomnographic (PSG) outcomes on CPAP at the prescribed pressure
| PSG outcome (per protocol) | Manual (n=59) | Laboratory APAP (n=64) | Home APAP (n=62) | p Value |
| Total recording time, min | 467±70 | 457±71 | 464±57 | 0.7 |
| Total sleep time, min | 351±79 | 345±74 | 364±71 | 0.4 |
| Stage 1+2, min | 257±62 | 248±59 | 264±61 | 0.3 |
| Stage 3+4, min | 34±32 | 31±26 | 32±22 | 0.8 |
| Stage REM, min | 63±35 | 67±33 | 71±31 | 0.4 |
| AHI, events/h slept | 7.1 (3.9–16) | 6.7 (4.1–14) | 8.0 (5.2–14) | 0.8 |
| Arousal index, events/h slept | 23±12 | 24±12 | 22±9 | 0.6 |
| Oxygen saturation time <90%, min | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0.8 |
| Oxygen saturation average, % | 95.±8 2 | 95.7±2 | 96.0±2 | 0.5 |
| Oxygen saturation lowest, % | 89.0±13 | 88.2±12 | 90.1±5 | 0.6 |
| Median mask leak, l/min | 3.6 (0–10.8) | 1.2 (0–8.1) | 1.2 (0–6.0) | 0.16 |
| 95th centile mask leak, l/min | 20.4 (9–37.8) | 12.6 (7.2–29.7) | 14.4 (6–26.4) | 0.24 |
Data are presented as mean±SD or median (IQR).
CPAP use = average nightly ‘mask on’ time.
Five per protocol patients did not have overnight PSG at week 4 (3 manual, 1 laboratory APAP, 1 home APAP titration).
AHI, apnoea/hypopnoea index; APAP, automatic positive airway pressure; CPAP, continuous positive airway pressure; REM, rapid eye movement.