Airway function and inflammatory markers in RSV and control groups at age 18 years
| RSV (n=46) | Control (n=92) | 95% CI for difference | |
| Resting | |||
| FEV1 (z-score) | −0.28 (0.93) | 0.11 (1.08) | 0.00 to 0.7* |
| FEV1/FVC (z-score) | −0.68 (0.85) | −0.08 (1.03) | 0.24 to 0.97** |
| FEF25–75 (z-score) | −0.60 (0.77) | −0.05 (0.85) | 0.25 to 0.86*** |
| LCI | 6.63 (0.52) | 6.59 (0.43) | −0.21 to 0.13 |
| Challenge (DACh) | |||
| Fall in FEV1 (%) | 4.7 (0.0–37.8) | 3.1 (0.0–42.8) | 0.0 to 3.2* |
| Post-bronchodilation | |||
| Rise in FEV1 (%) | 5.9 (0.0–10.5) | 3.1 (0.0–10.4) | 0.5 to 3.4** |
| FEV1 (z-score) | 0.16 (0.71) | 0.38 (1.30) | -0.18 to 0.61 |
| FEV1/FVC (z-score) | −0.04 (0.88) | 0.42 (0.95) | 0.11 to 0.80** |
| FEF25–75 (z-score) | −0.01 (0.78) | 0.38 (0.83) | 0.09 to 0.69* |
| Inflammatory markers | |||
| FeNO (ppb) | 14 (6–84) | 13 (5–74) | −1 to 5 |
| Blood eosinophil counts (×109/l) | 0.20 (0.04–0.57) | 0.14 (0.01–0.79) | 0.01 to 0.10** |
Data are shown as mean (SD) or median (range).
For normally distributed data, differences between the two groups are shown with 95% CI for the mean values and for non-normally distributed data as the 95% CI for the medians.
*p<0.05, **p<0.01, ***p<0.001.
For exact number of subjects in RSV and control group performing each test, see Table 1.
DACh, isocapnic dry air hyperventilation challenge; FEF25–75, forced expiratory fraction at 25–75% forced vital capacity; FeNO, fraction exhaled nitric oxide; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; LCI, lung clearance index; ppb, parts per billion; RSV, respiratory syncytial virus.