n | Costs for scheduled care | Costs for non-scheduled care | Total costs | Total costs per patient | Total costs per patient per month‡ | |
(A) Results with 4RIF | ||||||
Completed therapy | ||||||
No symptoms or problems | 180 | $154153 | $5278 | $159431 | $886 | $219 |
Had symptoms but completed | 148 | $130031 | $7139 | $137170 | $927 | $232 |
Did not complete, default | ||||||
Never started* | 2 | $392 | $0 | $392 | $196 | – |
Patient default, no symptoms | 49 | $21202 | $237 | $21339 | $435 | $279 |
Had symptoms, and patient defaulted | 17 | $9289 | $1440 | $10729 | $631 | $379 |
Drugs permanently stopped by physician† | ||||||
Drug-related adverse events | 16 | $4954 | $7468 | $12422 | $776 | $565 |
Pregnancy | 1 | $251 | $233 | $484 | $484 | $484 |
Not a drug-related adverse event | 9 | $2751 | $3889 | $6640 | $738 | $487 |
(B) Results with 9INH | ||||||
Completed therapy | ||||||
No symptoms or problems | 119 | $119297 | $8344 | $127641 | $1073 | $120 |
Had symptoms but completed | 136 | $142250 | $11551 | $153801 | $1131 | $126 |
Did not complete, default | ||||||
Never started* | 5 | $970 | $0 | $970 | $194 | – |
Patient default, no symptoms | 80 | $37948 | $1992 | $39940 | $499 | $260 |
Had symptoms and patient defaulted | 48 | $28409 | $1827 | $30236 | $630 | $194 |
Study drug stopped permanently by physician† | ||||||
Drug-related adverse events | 24 | $8855 | $17051 | $25906 | $1079 | $357 |
Pregnancy or death | 4 | $1797 | $1215 | $3012 | $753 | $217 |
Not a drug-related adverse event | 16 | $7312 | $6161 | $13473 | $842 | $258 |
↵* Patients consented, were randomised, but then refused to start treatment. Costs are for baseline evaluation only.
↵† Final designation regarding whether drugs were stopped appropriately and severity/relationship to study drug were made by an independent panel, blinded to study drug.
↵‡ Patient-months calculated from total number (sum) of patient-months on treatment within each group.
9INH, isoniazid treatment for 9 months; 4RIF, rifampin treatment for 4 months.