4RIF | 9INH | p Value* | |||||
Total cost | Total per patient allocated | Total per patient completed | Total cost | Total per patient allocated | Total per patient completed | ||
Scheduled care | |||||||
Clinical visits | |||||||
Baseline | $68334 | $69473 | |||||
MD±RN follow-up | $94177 | $152842 | |||||
RN follow-up | $39611 | $73005 | |||||
Subtotal clinical visits | $202122 | $481 | $616 | $295320 | $692 | $1158 | |
Medication | |||||||
Pharmacy fees | $10373 | $20251 | |||||
Drugs for LTBI | $94825 | $25609 | |||||
Subtotal treatment of LTBI | $105198 | $250 | $321 | $45860 | $107 | $180 | |
Investigations | |||||||
Complete blood count (CBC) | $11628 | $11277 | |||||
Liver transaminases | $14057 | $13681 | |||||
Subtotal investigations | $25684 | $61 | $78 | $24958 | $58 | $98 | |
Subtotal: scheduled care | $333005 | $792 | $1015 | $366138 | $857 | $1436 | 0.026 |
Non-scheduled care | |||||||
Clinical visits | |||||||
Emergency room visit | $179 | $894 | |||||
Unscheduled clinic visit | $701 | $1051 | |||||
Specialist consultation | $2937 | $3247 | |||||
Visit to evaluate adverse events | $9415 | $18691 | |||||
Telephone call | $46 | $162 | |||||
Visit to perform blood tests | $725 | $1670 | |||||
Subtotal clinical visits | $14003 | $33 | $43 | $25715 | $60 | $101 | |
Subtotal treatment for side effects | $218 | $1 | $1 | $226 | $1 | $1 | |
Investigations | |||||||
Additional CBC | $3635 | $7726 | |||||
Additional liver transaminases | $4766 | $10966 | |||||
Other investigations | |||||||
Blood chemistries | $844 | $910 | |||||
Hepatitis serology | $256 | $425 | |||||
Iron or coagulation profile | $233 | $337 | |||||
Other blood tests | $280 | $440 | |||||
Urinalysis | $21 | $42 | |||||
Pulmonary function tests | $352 | $440 | |||||
Procedures | $1027 | $546 | |||||
Imaging | $50 | $369 | |||||
Subtotal investigations | $11464 | $27 | $35 | $22201 | $52 | $87 | |
Subtotal: non-scheduled care | $25685 | $61 | $79 | $48142 | $113 | $189 | 0.008 |
Overall total costs | $358690 | 854 | 1094 | $414280 | $970 | $1625 | <0.0001 |
↵* Student t test comparing differences in costs per patient allocated to 4RIF vs 9INH. Differences in cost per patient completed greater, hence more significant. Total and subtotal costs normally distributed. Only three differences were tested.
9INH, isoniazid treatment for 9 months; LTBI, latent tuberculosis infection. 4RIF, rifampin treatment for 4 months