Recommended doses of first-line drugs in chronic kidney disease (CKD)
| Stage 1–3 CKD* | Stage 4 and 5 CKD* † | Renal transplant recipients | |
| Isoniazid | 300 mg daily | 300 mg daily or 15 mg/kg max 900 mg 3×/week | 300 mg daily |
| Rifampicin | <50 kg: 450 mg daily ≥50 kg: 600 mg daily | <50 kg: 450 mg daily ≥50 kg: 600 mg daily | <50 kg: 450 mg daily ≥50 kg: 600 mg daily |
| Pyrazinamide‡ | <50 kg: 1.5 g daily ≥50 kg: 2 g daily | 25–30 mg/kg 3×/week | <50 kg: 1.5 g daily ≥50 kg: 2 g daily |
| Ethambutol§ | 15 mg/kg daily | 15–25 mg/kg 3×/week (max 2.5 g) | 15 mg/kg daily |
| Moxifloxacin | 400 mg daily | Not suitable for 3× weekly regimen | 400 mg daily |
Isoniazid and rifampicin may be given intravenously where absorption is compromised. Dose: Isoniazid 300 mg as single daily dose; rifampicin 450 mg or 600 mg depending on weight by infusion over 2–3 h.
↵* See box 1.
↵† Also applies to dialysis.
↵‡ Check uric acid and monitor for gout.
↵§ Check baseline colour vision and visual acuity and warn patients to report any changes in red/green discrimination or visual acuity. Check peak and trough drug levels.