Outcome | Window size | Best global p value | Loci | Best individual p value | Best individual haplotype | OR (95% CI) | PAR |
Asthma | 2 | 0.0005 | 10, 11 | 0.0004 | GC (15%) | 1.66 (1.25 to 2.21) | 9.01 |
3 | 0.002 | 10, 11, 12 | 0.002 | GCA (15%) | 1.57 (1.18 to 2.10) | 7.88 | |
4 | 0.001 | 10, 11, 12, 13 | 0.001 | GCAC (15%) | 1.67 (1.22 to 2.29) | 9.13 | |
Atopy | 2 | 0.004 | 10, 11 | 0.001 | GT (30%) | 1.27 (1.10 to 1.46) | 7.49 |
3 | 0.012 | 10, 11, 12 | 0.0012 | GTA (30%) | 1.26 (1.10 to 1.45) | 7.23 | |
4 | 0.019 | 10, 11, 12, 13 | 0.001 | GTAC (28%) | 1.23 (1.11 to 1.53) | 6.05 | |
Atopic asthma | 2 | 0.0007 | 10, 11 | 0.001 | GC (15%) | 1.78 (1.26 to 2.51) | 10.47 |
3 | 0.0006 | 10, 11, 12 | 0.004 | GCA (15%) | 1.66 (1.18 to 2.35) | 9.01 | |
4 | 0.0003 | 10, 11, 12, 13 | 0.004 | GCAC (15%) | 1.72 (1.19 to 2.51) | 9.75 |
Model adjusted by country, body mass index, age, sex and smoking status.
Locus 10: rs184448; locus 11: rs324396; locus 12: rs324957; locus 13: rs324960.
PAR, population attributable risk.