Table 3

Haplotype analysis of NPSR1 with sliding windows

OutcomeWindow sizeBest global p valueLociBest individual p valueBest individual haplotypeOR (95% CI)PAR
Asthma20.000510, 110.0004GC (15%)1.66 (1.25 to 2.21)9.01
30.00210, 11, 120.002GCA (15%)1.57 (1.18 to 2.10)7.88
40.00110, 11, 12, 130.001GCAC (15%)1.67 (1.22 to 2.29)9.13
Atopy20.00410, 110.001GT (30%)1.27 (1.10 to 1.46)7.49
30.01210, 11, 120.0012GTA (30%)1.26 (1.10 to 1.45)7.23
40.01910, 11, 12, 130.001GTAC (28%)1.23 (1.11 to 1.53)6.05
Atopic asthma20.000710, 110.001GC (15%)1.78 (1.26 to 2.51)10.47
30.000610, 11, 120.004GCA (15%)1.66 (1.18 to 2.35)9.01
40.000310, 11, 12, 130.004GCAC (15%)1.72 (1.19 to 2.51)9.75
  • Model adjusted by country, body mass index, age, sex and smoking status.

  • Locus 10: rs184448; locus 11: rs324396; locus 12: rs324957; locus 13: rs324960.

  • PAR, population attributable risk.