Table 2

Nominal significant associations (p<0.05) between single nucleotide polymorphisms (SNPs) and persistent asthma, persistent atopy and persistent bronchial hyper-responsiveness (BHR) under the additive genetic model

Gene	SNP	Asthma		Atopy		BHR
Gene	SNP	OR (95% CI)	p Value	OR (95% CI)	p Value	OR (95% CI)	p Value
ADAM33	rs2787095	1.06 (0.87 to 1.29)	0.5403	1.12 (0.99 to 1.27)	0.0626	1.23 (1.01 to 1.5)	0.0382
NPSR1	rs714588	1.04 (0.86 to 1.27)	0.6709	0.87 (0.77 to 0.99)	0.0285	0.90 (0.74 to 1.11)	0.3245
NPSR1	rs1345267	0.81 (0.66 to 1.00)	0.0436	0.91 (0.80 to 1.03)	0.1326	0.94 (0.76 to 1.16)	0.5622
NPSR1	rs184448	1.48 (1.20 to 1.82)	0.0002	1.20 (1.06 to 1.36)	0.0049	1.14 (0.93 to 1.4)	0.2111
NPSR1	rs324396	1.21 (0.97 to 1.51)	0.0868	1.25 (1.09 to 1.43)	0.0010	1.16 (0.94 to 1.45)	0.1721
NPSR1	rs324957	1.41 (1.15 to 1.74)	0.001	1.20 (1.05 to 1.36)	0.0051	1.14 (0.93 to 1.40)	0.1999
NPSR1	rs324960	0.74 (0.60 to 0.93)	0.008	0.85 (0.74 to 0.97)	0.0140	0.93 (0.75 to 1.16)	0.5270
NPSR1	rs324981	0.69 (0.56 to 0.85)	0.0004	0.84 (0.74 to 0.95)	0.0064	0.87 (0.71 to 1.06)	0.1591
NPSR1	rs325462	0.76 (0.62 to 0.93)	0.0085	0.88 (0.78 to 0.99)	0.0367	0.86 (0.71 to 1.05)	0.1356

Model adjusted by country, body mass index, age, sex and smoking status.