Characteristics of the study population
| IPAH (n=10) | Controls (n=10) | p Value | |
| Demographics | |||
| Age (years) | 40 (30–55) | 38 (30–55) | 0.88 |
| Sex (F/M) | 7/3 | 7/3 | 1.00* |
| BMI (kg/m2) | 25 (23–28) | 24 (21–29) | 0.76 |
| Pulmonary haemodynamic | |||
| RAP (mm Hg) | 8 (7–8) | NA | NA |
| mPAP (mm Hg) | 40 (33–60) | ||
| CI 1/min.m2 | 3.2 (2.2–3.7) | ||
| PVRi (WU/m2) | 14 (7–17) | ||
| Exercise capacity | |||
| IET | |||
| V̇O2 max (ml/kg/min) | 18.4 (14.8–22.3) | 31.3 (28.3–34.1) | <0.01 |
| V̇O2 max (% pred) | 55 (45–61) | 100 (85–111) | <0.01 |
| V̇E/V̇CO2 slope | 43 (37–56) | 31 (27–32) | <0.01 |
| 6MWT | |||
| Distance (metres) | 448 (401–456) | 679 (619–690) | <0.01 |
| % predicted (%) | 70 (67–73) | 106 (97–108) | <0.01 |
Values are median (IQR).
↵* Analysed by Fisher exact test.
BMI, body mass index; CI, cardiac index; F, female; IET, incremental exercise test; IPAH, idiopathic pulmonary arterial hypertension; M, male; mPAP, mean pulmonary artery pressure; 6MWT, 6 minute walk test; % pred, percentage of predicted value; PVRi, pulmonary vascular resistance index; RAP, right atrial pressure; V̇CO2, volume of carbon dioxide expired; V̇E, minute ventilation; V̇O2, oxygen uptake; WU, Wood units.