Table 3

Incidence and hazard ratios for recurrent tuberculosis, England and Wales, 1998–2005

Category	Level	Subjects	Events	Incidence per 1000 years	Univariable			Multivariable (N=42 473)
Category	Level	Subjects	Events	Incidence per 1000 years	HR	95% CI	p Value	HR	95% CI	p Value
All		42 558	588	4.1 (3.8–4.5)	–	–	–	–	–	–
Sex	Female	19 387	274	4.2 (3.8–4.7)	Ref		0.64	Ref		0.57
Sex	Male	23 102	314	4.1 (3.6–4.5)	0.96	0.82 to 1.13		0.95	0.81 to 1.12
Age group	0–14	2700	15	1.6 (1.0–2.7)	0.33	0.2 to 0.56	<0.001	0.37	0.22 to 0.62	<0.001
	15–44	24 493	377	4.8 (4.4–5.4)	Ref			Ref
	45–64	8606	125	4.2 (3.5–5.0)	0.89	0.72 to 1.09		0.94	0.76 to 1.16
	65+	6742	71	2.8 (2.2–3.5)	0.60	0.47 to 0.78		0.66	0.50 to 0.86
Region	London	18 260	270	4.5 (4.0–5.1)	Ref		0.07	Ref		0.07
Region	Not London	24 298	318	3.8 (3.4–4.3)	0.86	0.73 to 1.01		0.85	0.71 to 1.01
Country of birth	UK born	12 801	175	3.7 (3.2–4.3)	Ref		0.49	–	–	–
	Non-UK born	25 042	343	4.3 (3.9–4.8)	0.90	0.75 to 1.08		–	–	–
	Unknown	4715	70	4.3 (3.4–5.4)	1.00	0.77 to 1.30		–	–	–
Ethnic group	White	11 255	133	3.1 (2.6–3.7)	Ref		0.02	Ref		<0.001
	Black Caribbean	1111	16	4.2 (2.6–6.9)	1.29	0.77 to 2.17		1.17	0.69 to 1.99
	Black African	8024	95	4.1 (3.4–5.0)	1.20	0.93 to 1.57		0.99	0.73 to 1.34
	South Asian	15 720	255	4.8 (4.2–5.4)	1.48	1.12 to 1.82		1.54	1.23 to 1.93
	Chinese	611	10	4.9 (2.6–9.2)	1.52	0.80 to 2.90		1.44	0.75 to 2.75
	Other	3789	44	3.9 (2.9–5.3)	1.16	0.82 to 1.63		1.07	0.77 to 1.54
	Unknown	2048	35	5.0 (3.6–7.0)	1.51	1.04 to 2.19		1.60	1.09 to 2.34
Site of disease	Pulmonary	21 539	348	4.8 (4.3–5.3)	1.24	1.00 to 1.55	<0.001	Ref		<0.001
	Pulmonary+ extrapulmonary	2645	50	5.5 (4.2–7.3)	1.45	1.04 to 2.04		1.07	0.79 to 1.44
	Pleural	2107	15	2.2 (1.3–3.7)	0.57	0.33 to 0.98		0.42	0.25 to 0.72
	Lymph node	8208	104	3.9 (3.2–4.7)	Ref			0.72	0.57 to 0.91
	Bone	1505	9	1.8 (0.9–3.4)	0.46	0.23 to 0.90		0.34	0.17 to 0.65
	CNS	807	8	3.0 (1.5–6.0)	0.78	0.38 to 1.60		0.59	0.29 to 1.19
	Miliary	929	14	4.7 (2.8–7.9)	1.2	0.69 to 2.10		0.86	0.50 to 1.48
	>2 extrapulmonary sites	1072	10	2.8 (1.5–5.3)	0.74	0.38 to 1.40		0.51	0.27 to 0.96
	Other extrapulmonary	3746	30	2.5 (1.7–3.5)	0.64	0.42 to 0.96		0.48	0.33 to 0.70
Culture	Not positive	17 694	208	3.4 (3.0–3.9)	Ref		<0.001	0.87	0.72 to 1.03	0.11
Culture	Positive	24 864	380	4.6 (4.2–5.1)	1.34	1.12 to 1.58		Ref
Isoniazid*	Sensitive	21 502	338	4.8 (4.3–5.3)	Ref		0.52	-	–	–
Isoniazid*	Resistant	1328	17	4.2 (2.6–6.7)	0.85	0.52 to 1.39		-	–	–
HIV	Not known +ve	40 637	554	4.0 (3.7–4.3)	Ref		<0.01	Ref		0.01
HIV	Positive	1921	34	7.6 (5.4–10.7)	1.65	1.17 to 2.34		1.64	1.13 to 2.38

↵* Isolates with known susceptibility results.
Event=re-notification, South Asian, Indian, Pakistani and Bangladeshi ethnic groups.