Ventilator settings, pneumotachographic measurements of ventilation parameters, treatment compliance and days in hospital needed for NPPV acclimatisation: high-intensity versus low-intensity NPPV
| Period | LI-NPPV | HI-NPPV | Difference between treatments (95% CI) | p Value | |
| IPAP (mbar) | 14.6±0.8 | 28.6±1.9 | |||
| EPAP (mbar) | 4.0±0 | 4.5±0.7 | |||
| Bf (/min) | 8.0±0 | 17.5±2.1 | |||
| Supplemental oxygen (l/min) | 2.2±0.8 | 2.2±0.8 | |||
| Vinsp (ml) | Period 1 | 821±257 | 1183±486 | 325 (159 to 492) | 0.002 |
| Period 2 | 846±356 | 1195±213 | |||
| Vexp (ml) | Period 1 | 351±161 | 414±218 | 96 (23 to 169) | 0.015 |
| Period 2 | 289±130 | 415±169 | |||
| Vleak (ml) | Period 1 | 469±336 | 769±674 | 226 (928 to 425) | 0.030 |
| Period 2 | 557±470 | 780±317 | |||
| RR (/min) | Period 1 | 15.4±3.5 | 17.8±3.7 | −0.5 (−3.4 to 2.4) | 0.71 |
| Period 2 | 18.9±5.1 | 15.3±1.3 | |||
| PIP (mbar) | Period 1 | 11.4±2.6 | 23.8±4.8 | 11.9 (9.5 to 14.3) | <0.001 |
| Period 2 | 11.5±1.8 | 23.1±2.0 | |||
| Mean daily use of ventilator (h/day) | Period 1 | 7.7±3.0 | 10.8±4.7 | 3.6 (0.6 to 6.7) | 0.024 |
| Period 2 | 4.6±1.8 | 8.9±6.4 | |||
| Number of days for initiation of NPPV | Period 1 | 1.7±1.6 | 4.6±1.9 | 2.5 (1.3 to 3.7) | 0.001 |
| Period 2 | 1.6±0.8 | 3.7±1.0 |
Data are presented as mean±SD.
Bf, breathing frequency; EPAP, expiratory positive airway pressure; HI-NPPV, high-intensity non-invasive positive pressure ventilation; IPAP, inspiratory positive airway pressure; LI-NPPV, low-intensity non-invasive positive pressure ventilation; PIP, peak inspiratory pressure; RR, respiratory rate; Vexp, expiratory volume; Vinsp, inspiratory volume; Vleak, leak volume.