Table 3

ORs and 95% CI for asthma symptoms and per mm increase in fetal measurement

5-Year outcome	Crown–rump length (continuous variable, mm)			Crown–rump length (class variable, quartiles)			Biparietal diameter (continuous variable, mm)			Femur length (continuous variable, mm)
5-Year outcome	OR	95% CI	p Value	OR	95% CI	p Value	OR	95% CI	p Value	OR	95% CI	p Value
Ever wheeze	0.96 n=498	0.93 to 0.99	0.034	0.68 n=498	0.49 to 0.96	0.028	0.94 n=877	0.88 to 1.02	0.119	0.97 n=869	0.89 to 1.05	0.387
Wheeze in the last 12 months	0.97 n=501	0.93 to 1.01	0.175	0.71 n=501	0.47 to 1.06	0.089	0.97 n=880	0.89 to 1.06	0.467	0.98 n=872	0.90 to 1.08	0.743
Wheeze without cold in the last 12 months	0.94 n=501	0.89 to 1.00	0.051	0.70 n=501	0.32 to 1.05	0.070	0.92 n=880	0.82 to 1.03	0.163	1.01 n=872	0.89 to 1.15	0.858
Seen doctor with wheeze in last 12 months	0.98 n=501	0.93 to 1.02	0.305	0.66 n=501	0.33 to 1.34	0.252	0.95 n=880	0.86 to 1.04	0.265	0.96 n=872	0.86 to 1.07	0.490
Ever asthma	0.95 n=499	0.91 to 0.99	0.033	0.60 n=499	0.39 to 0.92	0.019	0.88 n=873	0.80 to 0.96	0.005	0.90 n=865	0.82 to 0.99	0.043
Doctor-confirmed asthma	0.96 n=499	0.91 to 1.00	0.043	0.59 n=499	0.38 to 0.91	0.018	0.88 n=873	0.80 to 0.97	0.008	0.90 n=865	0.81 to 0.99	0.047
Asthma and wheeze in last 12 months	0.96 n=499	0.92 to 1.01	0.138	0.58 n=499	0.35 to 0.96	0.033	0.93 n=873	0.84 to 1.04	0.186	0.95 n=865	0.84 to 1.06	0.356

Models adjusted for gestational age at scan, sex, maternal smoking status at first trimester scan, history of maternal asthma, birth order, Scottish Index of Multiple Deprivation (SIMD), birth weight, breast feeding, use of antibiotics by the child in the first year of life and maternal intake of vitamin C, vitamin D and zinc. n indicates the total number of individuals included in the analysis.