Associations of adult forced vital capacity (FVC)* with (A) individual childhood disadvantage factors and (B) the number of childhood disadvantage factors
| Men (N = 8201) | Women (N = 8633) | |||
| Adjusted difference in FVC† (ml) (95% CI) | p Value | Adjusted difference in FVC† (ml) (95% CI) | p Value | |
| (A) | ||||
| Baseline FVC (ml)‡ | 5347.3 | 3838.7 | ||
| Maternal asthma | 2.0 (−70.8 to 74.7) | 0.957 | 19.0 (−25.1 to 63.1) | 0.398 |
| Paternal asthma | −21.5 (−90.4 to 47.3) | 0.540 | −44.8 (−90.7 to 1.0) | 0.055 |
| Childhood asthma | −47.0 (−130.9 to 36.9) | 0.272 | −119.6 (−188.0 to −51.2) | 0.001 |
| Severe respiratory infection before 5 years | −37.5 (−92.3 to 17.2) | 0.179 | −31.0 (−68.2 to 6.1) | 0.101 |
| Maternal smoking | −7.0 (−45.9 to 31.9) | 0.724 | −8.8 (−36.0 to 18.4) | 0.524 |
| (B) | ||||
| Baseline FVC (ml)‡ | 5341.6 | 3840.4 | ||
| Number of childhood factors | ||||
| 1 | −6.4 (−39.9 to 27.1) | 0.709 | −24.4 (−48.0 to −0.8) | 0.043 |
| 2 | −60.0 (−120.0 to −0.1) | 0.050 | −44.8 (−85.9 to −3.6) | 0.033 |
| 3 | −64.6 (−204.2 to 75.0) | 0.364 | −177.5 (−276.4 to −78.6) | <0.001 |
| For comparison: | ||||
| Adult smoking status | ||||
| Former | 34.6 (−2.5 to 71.7) | 0.067 | 55.8 (30.1 to 81.4) | <0.001 |
| Current <10 cig/day | −25.4 (−69.0 to 18.2) | 0.253 | 14.0 (−15.5 to 43.5) | 0.352 |
| Current 10–20 cig/day | −15.8 (−61.0 to 29.5) | 0.495 | 37.7 (5.1 to 70.2) | 0.023 |
| Current >20 cig/day | −71.9 (−117.2 to −26.5) | 0.002 | −12.9 (−50.1 to 24.3) | 0.497 |
Analyses include 8201 measurements in men and 8633 measurements in women with complete data.
*As measured in ECRHS I and ECRHS II.
†Difference in FVC (A) between subjects with and subjects without childhood factor when adjusting for other childhood factors in the table and (B) between subjects with a specific number of childhood factors and subjects with zero childhood factors. Adjusted for smoking status, age at completed education, social class, age, height and centre.
‡Baseline FVC in never-smoking, high education, professional subjects of median age and median height with none of the childhood disadvantage factors.
§Estimates for adult smoking are presented in order to enable comparison of estimates. The estimates are from model B, but are practically identical in model A.