Associations of adult forced expiratory volume in 1 s (FEV1)* with (A) individual childhood disadvantage factors and (B) the number of childhood disadvantage factors
| Men | Women | |||
| Adjusted difference in FEV1† (ml) (95% CI) | p Value | Adjusted difference in FEV1† (ml) (95% CI) | p Value | |
| (A) | ||||
| Baseline FEV1 (ml)‡ | 4383 | 3191 | ||
| Maternal asthma | −49.2 (−111.6 to 13.3) | 0.123 | −24.7 (−61.9 to 12.5) | 0.193 |
| Paternal asthma | −102 (−161 to −43.2) | <0.001 | −58.2 (−96.9 to −19.6) | 0.003 |
| Childhood asthma | −288 (−360 to −216) | <0.001 | −147 (−204 to −89.0) | <0.001 |
| Severe respiratory infection <5 years | −70.1 (−117.1 to −23.2) | 0.003 | −28.2 (−59.5 to 3.1) | 0.077 |
| Maternal smoking | −44.5 (−77.9 to −11.2) | 0.009 | −30.5 (−53.4 to −7.6) | 0.009 |
| (B) | ||||
| Baseline FEV1 (ml)‡ | 4372 | 3198 | ||
| Number of childhood disadvantage factors | ||||
| 1 | −58.0 (−87.0 to −29.1) | <0.001 | −48.9 (−68.9 to −28.8) | <0.001 |
| 2 | −201 (−253 to −149) | <0.001 | −78.4 (−113 to −43.5) | <0.001 |
| ⩾3 | −274 (−395 to −154) | <0.001 | −208 (−292 to −124) | <0.001 |
| For comparison§ | ||||
| Adult smoking status | ||||
| Ex | 2.0 (−28.5 to 32.4) | 0.900 | 29.7 (8.8 to 50.6) | 0.005 |
| Current <10 cig/day | −45.8 (−81.0 to −10.6) | 0.011 | −6.7 (−30.4 to 17.1) | 0.583 |
| Current 10–20 cig/day | −77.0 (−114 to −40.5) | <0.001 | −16.5 (−42.6 to 9.6) | 0.215 |
| Current >20 cig/day | −112 (−149 to −74.9) | <0.001 | −75.6 (−105 to −45.8) | <0.001 |
Analyses include 8201 measurements in men and 8631 measurements in women with complete data.
*As measured in ECRHS I and ECRHS II.
†Difference in FEV1 (A) between subjects with and subjects without childhood factor when adjusting for other childhood factors in the table and (B) between subjects with a specific number of childhood factors and subjects with zero childhood factors. Adjusted for smoking status, age at completed education, social class, age, height and centre.
‡Baseline FEV1 in never-smoking, high education, professional subjects of median age and median height with none of the childhood disadvantage factors.
§Estimates for adult smoking are presented in order to enable comparison of estimates. The estimates are from model B, but are practically identical in model A.