Outcomes of INTERCOM compared with usual care after 4 months
| Health outcome | Mean (SE) change from baseline | Mean (SE) difference in change from baseline as observed | Adjusted difference in change from baseline* | p Value | |
| Usual care(n = 88) | INTERCOM(n = 87) | ||||
| SGRQ Total | 0.3 (1.0) | −3.9 (1.1) | 4.2 (1.5) | 4.1 (1.4) | 0.004 |
| SGRQ Activity | 0.9 (1.4) | −3.9 (1.5) | 4.8 (2.1) | 5.2 (2.0) | 0.01 |
| SGRQ Symptom | −1.4 (1.8) | −3.0 (1.9) | 1.6 (2.6) | 1.1 (2.3) | 0.64 |
| SGRQ Impact | 0.5 (1.3) | −4.1 (1.2) | 4.6 (1.8) | 4.3 (1.6) | <0.01 |
| MRC dyspnoea score | 0.1 (0.1) | −0.3 (0.1) | 0.4 (0.1) | 0.33 (0.13) | <0.01 |
| CET (s) | 29 (77) | 234 (79) | 205 (108) | 221 (104) | 0.04 |
| 6MWD (m) | −15.3 (3.9) | −1.4 (3.9) | 13.8 (5.5) | 13.3 (5.6) | 0.02 |
| Wmax (W) | −0.4 (1.7) | 5.2 (1.6) | 5.6 (2.3) | 6.0 (2.3) | 0.01 |
| HGF (lb) | −1.2 (1.2) | 2.9 (1.1) | 4.1 (1.5) | 4.3 (1.5) | <0.01 |
| QPT (Nm) | 2.4 (2.3) | −1.0 (2.2) | 3.4 (3.1) | 2.1 (3.1) | 0.51 |
| Pimax (kPa) | 0.06 (0.17) | 0.23 (0.16) | 0.16 (0.23) | 0.27 (0.21) | 0.21 |
| FFMI (kg/m2) | −0.23 (0.10) | 0.15 (0.08) | 0.38 (0.13) | 0.34 (0.13) | 0.01 |
| BMI (kg/m2) | 0.02 (0.10) | 0.28 (0.1) | 0.26 (0.15) | 0.23 (0.15) | 0.13 |
| FEV1 (% predicted) | −1.74 (1.04) | 0.87 (0.72) | 2.61 (1.27) | 2.75 (1.28) | 0.03 |
*Difference in change from baseline adjusted for the baseline value of the parameter, smoking status, FEV1 percentage predicted and the self-reported number of exacerbations during the 12 months preceding the trial.
BMI, body mass index; CET, cycle endurance test; FEV1, forced expiratory volume in 1 s; FFMI, fat-free mass index; HGF, handgrip force; 6MWD, 6-minute walking distance; QPT, isometric quadriceps peak torque; Pimax, maximal inspiratory mouth pressure; SGRQ, St George’s Respiratory Questionnaire; Wmax, peak exercise capacity.