Associations between maternal smoking and children's FEF25–75 stratified by maternal Nrf2 and GST genotype
| N | AM difference* | (95% CI) | p Value | ||
| Nrf2 | |||||
| C:C | 3174 | −0.05 | (−0.09 to −0.01) | 0.015 | |
| T:C | 894 | −0.01 | (−0.10 to 0.07) | 0.75 | |
| T:T | 67 | −0.16 | (−0.55 to 0.22) | 0.4 | |
| Interaction | 4135 | 0.62 | |||
| GSTT1 | |||||
| Present | 3235 | −0.06 | (−0.09 to −0.02) | 0.004 | |
| Absent | 649 | 0.03 | (−0.06 to 0.12) | 0.57 | |
| Interaction | 3884 | 0.1 | |||
| Copy number | |||||
| 2 | 1025 | −0.01 | (−0.07 to 0.06) | 0.84 | |
| 1 | 1649 | −0.09 | (−0.14 to −0.03) | 0.002 | |
| 0 | 649 | 0.03 | (−0.06 to 0.12) | 0.57 | |
| Interaction | 3323 | 0.06 | |||
| GSTM1 | |||||
| Present | 1851 | −0.02 | (−0.07 to 0.03) | 0.46 | |
| Absent | 2062 | −0.06 | (−0.10 to −0.01) | 0.02 | |
| Interaction | 3913 | 0.31 | |||
| Copy number | |||||
| 2 | 260 | 0.08 | (−0.08 to 0.24) | 0.31 | |
| 1 | 1442 | −0.03 | (−0.09 to 0.03) | 0.32 | |
| 0 | 2062 | −0.06 | (−0.10 to −0.01) | 0.02 | |
| Interaction | 3764 | 0.25 | |||
| GSTP1 | |||||
| A:A | 1728 | −0.05 | (−0.11 to 0.01) | 0.09 | |
| G:A | 1894 | −0.05 | (−0.10 to 0.00) | 0.07 | |
| G:G | 519 | −0.04 | (−0.14 to 0.05) | 0.38 | |
| Interaction | 4141 | 0.99 | |||
↵* Arithmetic mean difference of standard deviations (SDS) between categories, adjusted for smoking propensity (see methods for details).
AM, arithmetic mean; FEF25–75, maximal mid expiratory flow.