Simvastatin | Placebo | p Value | |
PC20AMP (mg/ml)* | 27.4 (12.2 to 61.6) | 47.6 (16.7 to 135.7) | 0.144 |
Eosinophils (%) | 9.5 (5.7–31.1) | 25.4 (15.2–48.2) | 0.033 |
Neutrophils (%) | 20.2 (11.3–51.3) | 16.1 (4.9–35.5) | 0.145 |
Macrophages (%) | 34.0 (19.9–56.9) | 28.6 (16.6–45.6) | 0.215 |
Lymphocytes (%) | 1.8 (0.7–3.0) | 0.7 (0.0–1.4) | 0.003 |
p Values are for comparisons between simvastatin and placebo; significant values are in bold.
Analysed using Wilcoxon signed rank tests.
Data are expressed as median (IQR).
↵* Analysed by paired t test after logarithmic transformation and results presented as geometric mean (95% CI).
PC20AMP, provocation concentration of AMP causing a 20% fall in forced expiratory volume in 1 s.