Phenotypes | Inflammatory patterns | p Value* | |||||
Non-eosinophilic pattern (n = 214) | Eosinophilic pattern (n = 167) | ||||||
EOSlo/NEUlo (n = 166) | EOSlo/NEUhi (n = 48) | p Value | EOShi/NEUlo (n = 132) | EOSlo/NEUhi (n = 35) | p Value | ||
Asthma attack (last 12 months), % | 68.2 | 62.2 | 0.4 | 79.2 | 79.4 | 1.0 | 0.009 |
Asthma event score, mean (SD)† | 2.17 (1.19) | 2.27 (1.23) | 0.6 | 2.55 (1.20) | 2.75 (1.21) | 0.4 | 0.003 |
Nocturnal symptoms (last 12 months): | |||||||
Woken by an attack of shortness of breath, % | 38.5 | 39.6 | 0.9 | 52.7 | 71.0 | 0.07 | 0.0002 |
Woken with chest tightness, % | 59.2 | 54.2 | 0.5 | 72.1 | 93.9 | 0.008 | 0.0008 |
Woken by an attack of coughing, % | 43.7 | 50.0 | 0.4 | 43.4 | 66.7 | 0.02 | 0.6 |
At least two nocturnal symptoms, % | 46.9 | 45.8 | 0.9 | 59.2 | 90.9 | 0.0006 | 0.0003 |
Attack of coughing excluded, % | 23.4 | 20.8 | 0.8 | 36.5 | 72.7 | 0.04 | 0.005 |
Symptomatic score, mean (SD)‡ | 2.71 (1.82) | 2.36 (1.96) | 0.3 | 3.25 (1.58) | 4.03 (1.24) | 0.01 | <0.0001 |
*Non-eosinophilic vs eosinophilic (crude p value).
†Based on frequency of attacks, symptoms between attacks, hospitalisation taking treatment into account (see the Methods section).
‡Based on the number of asthma symptoms (wheeze and breathlessness, woken with chest tightness, woken by attack of shortness of breath, attack of shortness of breath at rest, attack of shortness of breath after exercise) (see the Methods section).
EOS, eosinophils, NEU, neutrophils.