Associations of UGT1A1 haplotypes with serum total bilirubin levels: linear regression analysis
| LD block | Haplotype | Haplotype frequency (%) | Univariate analysis | Multivariate analysis* | ||
| Estimates (SE) | p Value | Estimates (SE) | p Value | |||
| Block 1† | ATTTTG | 52.8 | 1.0 | – | 1.0 | – |
| CCGTTG | 32.8 | 0.0698 (0.0215) | 0.0012 | 0.0712 (0.0189) | 0.0002 | |
| CTTGTG | 5.7 | −0.0169 (0.0422) | 0.689 | −0.0089 (0.0368) | 0.807 | |
| CTTGGA | 5.6 | 0.0737 (0.0410) | 0.073 | 0.0321 (0.0356) | 0.380 | |
| Others | 3.1 | – | – | – | – | |
| Block 3‡ | GTT | 73.6 | 1.0 | – | 1.0 | – |
| CCC | 20.4 | −0.0153 (0.0235) | 0.593 | −0.0240 (0.0206) | 0.244 | |
| CTT | 2.53 | −0.0313 (0.0585) | 0.581 | −0.0179 (0.0513) | 0.727 | |
| Others | 3.47 | – | – | – | – | |
*Adjustment for age, gender, septic shock, chronic liver diseases, history of alcohol use, history of steroid use, diabetes, modified APACHE (Acute Physiology and Chronic Health Evaluation) III scores and organ dysfunctions (respiratory, cardiovascular, renal and haematological).
†Polymorphisms are in the order: rs3755319–rs887829–rs6742078–rs3771342–rs17864705–rs1018124.
‡Polymorphisms are in the order: rs8330–rs1500482–rs4663972.
LD, linkage disequilibrium.