Table 1

Design of the COPE II study, including the two interventions (self-treatment of exacerbations and COPE-active) and the measurements at baseline, 7 and 12 months

Time schedule	Interventions	Self-treatment group (intervention group)		Control group
Time schedule	Interventions	Subgroup 1	Subgroup 2	Subgroup 3	Subgroup 4
Month 0	Baseline measurement	×	×	×	×
Month 1	Self-management courses	×	×	×	×
Month 1–12	Self-treatment of exacerbations	×	×	–	–
Month 2–7	COPE-active: “compulsory”	×	–	×	–
Month 7	Measurement	×	×	×	×
Month 8–12	COPE-active: “voluntary”	×	–	×	–
Month 12	Measurement	×	×	×	×