Table 2 Multivariate genetic association with asthma in the Western Australian Twin Child Health (WATCH) study and the Busselton Health Study (BHS)
SNPBusseltonWATCH
Genotype: coefficient (95% CI), p valuep Value*
rs9568221AG: 0.76 (0.55 to 1.05), p = 0.090.34
GG: 0.43 (0.07 to 2.50), p = 0.35
rs9568222AT: 1.35 (0.92 to 2.03), p = 0.14–†
TT: 1.68 (0.18 to 2.79), p = 0.96
rs6561527AT: 0.89 (0.63 to 1.25), p = 0.530.93
TT: 1.70 (0.87 to 3.34), p = 0.11
rs9568227GA and AA: 1.26 (0.87 to 1.84), p = 0.21‡0.88
rs2031532GA: 0.98 (0.77 to 1.25), p = 0.860.87
AA: 0.83 (0.58 to 1.20), p = 0.32
rs2247119CT: 0.99 (0.78 to 1.26), p = 0.980.60
CC: 1.11 (0.74 to 1.65), p = 0.62
rs9596127GT and TT: 1.12 (0.70 to 1.79), p = 0.62‡
rs9568232CT: 1.08 (0.76 to 1.52), p = 0.65
TT: 2.23 (0.19 to 25.2), p = 0.52
rs8000149TC: 1.013 (0.79 to 1.29), p = 0.910.69
CC: 0.82 (0.57 to 1.17), p = 0.29
rs17381926TC: 1.46 (0.93 to 2.28), p = 0.09
CC: 1.67 (0.97 to 2.84), p = 0.96
rs3765526CA: 1.02 (0.78 to 1.32), p = 0.870.54
AA: 0.93 (0.67 to 1.27), p = 0.64
rs17073051AG: 1.01 (0.77 to 1.31), p = 0.930.46
GG: 0.92 (0.67 to 1.27), p = 0.63
rs9526569TC: 0.99 (0.77 to 1.26), p = 0.940.90
CC: 0.83 (0.59 to 1.17), p = 0.30
rs1046295AG: 0.95 (0.73 to 1.24), p = 0.750.58
GG: 0.92 (0.67 to 1.26), p = 0.60
rs3794378AG: 1.07 (0.74 to 1.54), p = 0.690.96
GG: 1.22 (0.72 to 2.05), p = 0.44
rs9568238CT: 1.24 (0.90 to 1.70), p = 0.170.51
TT: 0.31 (0.05 to 1.66), p = 0.07
rs9562892CT: 1.28 (0.87 to 1.87), p = 0.190.45
TT: 0.18 (0.01 to 1.79), p = 0.14
rs1925742TC: 0.99 (0.79 to 1.26), p = 0.960.21
CC: 0.76 (0.50 to 1.13), p = 0.18
rs9535259GC: 0.82 (0.63 to 1.06), p = 0.130.58
CC: 0.72 (0.39 to 1.35), p = 0.32
  • *Only p values are shown here as transmission disequilibrium tests do not allow for estimations of odds ratios and 95% confidence intervals.

  • †Not tested due to low numbers of informative families to run the transmission disequilibrium test.

  • †The number of participants with minor homozygous genotypes was too small to allow comparison under a co-dominant model and have been examined instead under a dominant model.