Table 2

Comparison of SPD and sweat chloride concentration for all groups

	SPD-cholinergic (Protocol 1)				ΔSPDchol/β-adren (Protocol 2)		Sweat chloride-cholinergic
	(1) Test	p Value*	(2) Test	p Value*		p Value*		p Value*
HC	−14.4	0.6	−17.6	0.5	−0.1	0.5	23.5	0.7
	−16.6 to −8.1		−27.2 to −13.4		−3.6 to 5.2		11 to 42.4
	(9)		(9)		(8)		(10)
Hz	−16.0		−16.8		1.8		18
	−20.5 to −6.7		−19.6 to −8.3		−0.6 to 6.4		13.5 to 28.5
	(10)		(10)		(7)		(10)
CFPS	−41.3	0.5	−40.3	0.07	17.1	0.04	91	0.2
	−55.9 to −37.4		−51.2 to −28.5		12.3 to 19.8		68 to 103.5
	(10)		(5)		(8)		(8)
CFPI	−48.8		−55.2		24.0		104
	−56.8 to −43.5		−63.8 to −43.3		19.6 to 29.1		92.5 to 119.5
	(8)		(7)		(7)		(8)
HC + Hz	−14.5	<0.001	−17.6	<0.001	1.5	<0.001	21.5	<0.001
	−18.1 to −7.7		−19.7 to −11.3		−2.2 to 6.4		13.5 to 28.5
	(19)		(19)		(15)		(20)
CFPS + CFPI	−47.4		−46.4		19.8		98.5
	−56.1 to −39.1		−60.8 to −38.1		16.1 to 25.4		78.5 to 112
	(18)		(12)		(15)		(16)

All data are given as medians, interquartile range (IQR) and number of subjects (n).
CFPI, pancreatic-insufficient CF patients; CFPS, pancreatic-sufficient CF patients; HC, healthy controls; Hz, heterozygotes; SPD, sweat gland potential difference; ΔSPDchol/β-adren, sweat gland potential difference recorded after cholinergic followed immediately by β-adrenergic stimulation minus SPD recorded after cholinergic stimulation alone.
*Wilcoxon rank sum test.