Characteristics associated with mortality in multivariate analysis in 524 HIV-infected patients with PCP
| Died* (n = 54) | Survived (n = 470) | Bivariate, unadjusted RR (95% CI), p value | Multivariate, adjusted OR (95% CI), p value† | |
| Mean age, per 10-year increase | 43.6 (8.4) | 40.3 (7.9) | 1.64 (1.15 to 2.36), 0.01 | 1.69 (1.08 to 2.65), 0.02 |
| Recent injection drug use‡ | ||||
| Yes | 17 (18) | 78 (82) | 2.21 (1.19 to 4.10), 0.01 | 2.86 (1.28 to 6.42), 0.01 |
| No | 37 (9) | 374 (91) | ||
| CD4 cell count | ||||
| <50 cells/μl | 42 (12) | 304 (88) | 2.23 (1.09 to 4.56), 0.03 | 2.34 (0.95 to 5.80), 0.07 |
| ⩾50 cells/μl | 10 (6) | 159 (94) | ||
| Total bilirubin | ||||
| >0.6 mg/dl | 33 (18) | 152 (82) | 2.86 (1.59 to 5.14), <0.001 | 2.59 (1.19 to 5.62), 0.02 |
| ⩽0.6 mg/dl | 20 (7) | 265 (93) | ||
| Albumin | ||||
| <3 g/dl | 32 (17) | 151 (83) | 3.28 (1.77 to 6.10), <0.001 | 3.63 (1.72 to 7.66), 0.001 |
| ⩾3 g/dl | 17 (6) | 264 (94) | ||
| A–a O2 gradient | ||||
| ⩾50 mm Hg | 36 (19) | 153 (81) | 4.14 (2.13 to 8.05), <0.001 | 3.02 (1.41 to 6.47), 0.004 |
| <50 mm Hg | 13 (5) | 229 (95) |
*Values are shown as number (%) unless otherwise stated; means are presented with the SD.
†Forty-three deaths in 358 observations retained in the multivariate model.
‡Recent injection drug use is defined as drug use during the 6 months before admission.
PCP, Pneumocystis pneumonia; A–a O2 gradient, alveolar–arterial oxygen gradient.