Grade 3–4 haematological toxicity | GC(n = 120) | PE(n = 119) | 95% CI of absolute difference | p Value(χ2 test) |
Anaemia | 17 (14%) | 3 (2%) | 4% to 18% | 0.001 |
Leucopenia | 38 (32%) | 16 (13%) | 8% to 28% | 0.001 |
Neutropenia | 47 (39%) | 34 (28%) | 1% to 22% | 0.082 |
Platelets | 26 (22%) | 5 (4%) | 9% to 25% | <0.001 |
A total of 120 patients on GC and 119 patients on PE received at least one cycle of chemotherapy. One patient on GC did not receive allocated chemotherapy and one patient on PE progressed before cycle 1.
GC, gemcitabine and carboplatin; PE, cisplatin and etoposide.