Lung disease group | Study | Patient population | No of patients | Manometry | Abnormal distal reflux (%) | Abnormal proximal reflux (%) | Delayed gastric emptying | Comment |
Usual interstitial pneumonia | Tobin 199815 | IPF Clinic | 17 | Selected patients | 88 | 71% | Manometry not used | |
Raghu 200617 | IPF Clinic | 65 | Yes | 76 | 63 | Some subjects taking PPIs and pH probe placement varied | ||
Salvioli 200618 | IPF Clinic | 18 | Selected patients | 67 | Manometry not used | |||
Sweet 200719 | Pre-transplant | 30 | Yes | 67 | 30 | |||
Cystic fibrosis | Ledson 199826 | CF Clinic | 10 | Yes | 80 | Patients with symptoms selected | ||
Button 200523 | Pre-transplant | 11 | No | 91 | Undefined | Some subjects taking PPIs, 1 patient s/p fundoplication | ||
Button 200523 | Post-transplant | 13 | No | 85 | Undefined | Some subjects taking PPIs, 1 patient s/p fundoplication | ||
Bodet-Milin 200627 | Pre-transplant | 30 | 67% | |||||
Connective tissue disease | Johnson 198910 | Rheumatology Clinic | 13 | Yes | 54 | Undefined | ||
Bassotti 199729 | Dermatology Clinic | 78 | Yes | 78 | Acid suppression not withheld prior to study | |||
Gasper 2007* | Transplant Clinic | 23 | Yes | 83 | 30 | 6 of 8 (75%) | ||
COPD | Andersen 198930 | COPD Clinic | 55 | Yes | 49 | |||
Casanova 200431 | COPD Clinic | 42 | Yes | 62 | ||||
Pre-lung transplant | Cantu 200540 | Transplant Clinic | 36 | Yes | 63 | PPI withheld for 5 days | ||
D’Ovidio 200524 | Transplant Clinic | 78 | Yes | 32 | 20 | 13 of 27 (44%) | PPI withheld for 5 days | |
Sweet 200625 | Transplant Clinic | 109 | Yes | 68 | 37 | |||
Post-lung transplant | Cantu 200540 | Transplant Clinic | 167 | Yes | 76 | PPI withheld for 5 days | ||
Berkowitz 199546 | Transplant Clinic | 38 | 24% | Studied both lung and heart–lung transplant patients | ||||
D’Ovidio 200645 | Transplant Clinic | 50, 30 | Yes | 26, 50 | 0–14 and 10–17 | 39 of 43 (91%) | Patients studied at 2 time points: 3 and 12 months after transplant |
*Unpublished data.
COPD, chronic obstructive pulmonary disease; IPF, idiopathic pulmonary fibrosis; PPIs, proton pump inhibitors; s/p, status post.