Comparison of TST and IGRA responses in adults and children in recent household contact with a tuberculosis index case
| TST vs T-SPOT.TB | TST vs QTF | T-SPOT.TB vs QTF | ||||||||||
| Discordant results | Discordant results | Discordant results | ||||||||||
| % Agreement | T-SPOT.TB+ | T-SPOT .TB− | κ (95% CI) | % Agreement | QTF+ | QTF− | κ (95% CI) | % Agreement | T-SPOT.TB+ | T-SPOT.TB− | κ (95% CI) | |
| TST− | TST+ | TST− | TST+ | QTF− | QTF+ | |||||||
| All | 65.8 | 21.1% | 13.2% | 0.12 (−0.11 to 0.36) | 70.6 | 0% | 29.4% | 0.45 (0.28 to 0.62) | 66.7 | 31.9% | 1.5% | 0.38 (0.21 to 0.55) |
| Children | 46.1 | 46.2% | 7.7% | −0.15 (−35 to 0.05) | 88.9 | 0% | 11.1% | 0.78 (0.50 to 1.00) | 56.2* | 50% | 6.3% | −0.03 (−0.33 to 0.27) |
| Adults | 76.0 | 8% | 16% | 0.38 (0.10 to 0.66) | 60.0 | 0% | 36% | 0.34 (0.16 to 0.52) | 74 | 26.4% | 0% | 0.50 (0.31 to 0.70) |
CI, confidence interval; IGRA, interferon γ release assay; QTF: Quantiferon-Gold; TST: tuberculin skin test (TST positive: ⩾10 mm).
*Statistically significant (indeterminate results excluded).