Causes | Occupational asthma group (%) |
High molecular weight agents | |
Total | 21 |
Latex | 7 |
Flour | 5 |
Enzymes | 6 |
Other | 3 |
Low molecular weight agents | |
Total | 79 |
Cleaning agents | 17 |
Isocyanates | 18 |
Solder flux flume | 8 |
Metal working fluid | 7 |
Metals | 5 |
Adhesives | 7 |
Other | 17 |
Methods of independent diagnosis | |
Challenge positive | 59 |
Asthma + IgE +history alone | 26 |
NSBR×4 alone | 15 |
NSBR, non-specific bronchial reactivity; a fourfold change was needed between work and rest periods for inclusion.