Variable | Pred arm n = 31 | Placebo arm n = 29 | P Value Pred vs placebo |
Group characteristics | |||
FEV1 (% predicted) | 98 (92 to 104) | 91 (85 to 97) | 0.26 |
Aspirin sensitivity | n = 15 | n = 15 | 0.89 |
Asthma | n = 11 | n = 11 | 0.23 |
Total IgE (kU/l)* | 93.6 (57.6 to 151.9) | 101.7 (56.4 to 183.6) | 0.43 |
Methacholine PC20 (mg/ml)* | 1.2 (0.5 to 3.1) | 1.6 (0.9 to 2.8) | 0.65 |
Mini RQLQ (units) | |||
Baseline | 1.62 (1.23 to 2.01) | 2.17 (1.51 to 2.83) | 0.75 |
Post tablets | 0.75 (0.33 to 1.16)† | 1.73 (1.21 to 2.24) | 0.001 |
Post nasal drops | 0.75 (0.46 to 1.03)† | 0.69 (0.45 to 0.94)† | 0.25 |
Post nasal spray | 0.66 (0.45 to 0.87)† | 1.08 (0.72 to 1.44)† | 0.12 |
PNIF (l/min) | |||
Baseline | 111 (95 to 127) | 111 (79 to 143) | 0.92 |
Post tablets | 145 (128 to 163)† | 133 (100 to 166) | 0.11 |
Post nasal drops | 148 (131 to 165)† | 160 (126 to 195)† | 0.75 |
Post nasal spray | 147 (129 to 165)† | 146 (110 to 183) | 0.59 |
Anosmia score (0–100 mm) | |||
Baseline | 62.04 (49.01 to 75.06) | 55.58 (40.90 to 70.26) | 0.75 |
Post tablets | 32.96 (22.23 to 43.69)† | 59.50 (47.43 to 71.57) | 0.001 |
Post nasal drops | 33.69 (22.48 to 44.90)† | 43.98 (30.88 to 57.08) | 0.25 |
Post nasal spray | 34.65 (23.79 to 45.52)† | 47.25 (34.56 to 59.94) | 0.12 |
Endoscopy score (0–6) | |||
Baseline | 4.7 (4 to 5.5) | 4.8 (4 to 6) | 0.66 |
Post tablets | 2.6 (2 to 3)† | 4.7 (4 to 5) | <0.001 |
Post nasal drops | 2.2 (1 to 3.5)† | 3.2 (3 to 4)† | 0.002 |
Post nasal spray | 2.8 (2 to 4)† | 3.3 (2 to 4)† | 0.04 |
OUCC* (nmol/mmol) | |||
Baseline | 8.07 (6.27 to 10.40) | 8.70 (7.04 to 10.73) | 0.93 |
Post tablets | 14.52 (8.95 to 23.55) | 7.62 (6.39 to 9.09) | 0.03 |
Post nasal drops | 7.74 (5.79 to 10.37) | 7.48 (5.98 to 9.35) | 0.68 |
Post nasal spray | 8.51 (6.36 to 11.35) | 8.14 (6.38 to 10.42) | 0.83 |
*Indicates geometric mean and 95% CI. †Indicates statistically significant change from baseline values (p<0.05). RQLQ, rhinoconjunctivitis quality of life questionnaire; PNIF, peak nasal inspiratory flow rate; Pred, prednisolone 25 mg od for 2 weeks.