Variable | Baseline | Post step-down | p Value |
BDP equivalent ICS dose (μg/day) | 635.96 (35.7) | 357.02 (18.9) | <0.001 |
Mannitol (PD10 mg/ml)† | 99.99 (1.15) | 137.19 (1.15) | 0.04 |
Exhaled nitric oxide† | 26.79 (1.10) | 27.93 (1.09) | 0.43 |
Spirometry‡ | |||
FEV1 % predicted | 86.16 (1.51) | 84.46 (1.46) | 0.04 |
FVC % predicted | 91.56 (1.38) | 91.52 (1.44) | 0.97 |
PEF % predicted | 90.20 (1.70) | 90.02 (1.56) | 0.87 |
AQLQ | |||
Average score per question | 5.45 (0.10) | 5.83 (0.09) | <0.001 |
Symptoms | 26.11 (0.55) | 28.23 (0.51) | <0.001 |
Activity limitations | 25.91 (0.63) | 28.38 (0.55) | <0.001 |
Emotional function | 27.18 (0.54) | 28.96 (0.51) | <0.001 |
Environmental stimuli | 27.00 (0.56) | 29.09 (0.49) | <0.001 |
Total score | 81.60 (1.50) | 87.40 (1.38) | <0.001 |
*Data presented as arithmetic mean (SEM) unless otherwise indicated. Baseline values are shown after washout before each randomised treatment period. †Shown as geometric mean (geometric SEM). ‡Expressed as a percentage of that predicted by age, sex, and height. AQLQ, asthma quality of life questionnaire; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; ICS, inhaled corticosteroids; PC10, provocative concentration of mannitol causing a 10% decrease in FEV1; PEF, peak expiratory flow rate.