Table 4

Predictors of overall survival (mortality as determined by Cox’s proportional hazards regression)

HR (95% CI)p Value
Right heart catheterisation
    PVR1.13 (1.05 to 1.22)0.001*
    PVR index1.07 (1.03 to 1.12)0.003*
    mPAP1.02 (0.99 to 1.05)0.25
    mRAP0.96 (0.87 to 1.05)0.32
    mLAP0.94 (0.88 to 1.00)0.05
    Cardiac output0.86 (0.63 to 1.18)0.34
    Cardiac index0.69 (0.36 to 1.33)0.27
Echocardiography
    RV dilation1.92 (0.93 to 3.98)0.08
    RV dysfunction1.72 (0.84 to 3.53)0.14
    RVSP1.00 (0.98 to 1.02)0.81
Pulmonary function
    Tlco %0.94 (0.91 to 0.98)0.001
    Kco %0.98 (0.96 to 0.99)0.03
    FVC %0.98 (0.96 to 0.99)0.02
    Composite physiological index1.06 (1.03 to 1.10)<0.0001†
    Pao20.73 (0.60 to 0.89)0.002
Clinical
    Male gender2.10 (0.96 to 4.57)0.06
    Age1.01 (0.98 to 1.04)0.47
    IPF diagnosis3.33 (1.58 to 7.00)0.001
    WHO class1.85 (1.19 to 2.88)0.006

  • *Significant following adjustment for age, gender and CPI (PVR: HR 1.13, 95% CI 1.03 to 1.23, p = 0.009; PVR index: HR 1.24, 95% CI 1.11 to 1.38; p<0.001).

  • †Significant following adjustment for age, gender and PVR (CPI: HR 1.06, 95% CI 1.03 to 1.10, p = 0.001).

  • CI, confidence interval; FVC, forced vital capacity; HR, hazards ratio; IPF, idiopathic pulmonary fibrosis; Kco, transfer factor corrected for alveolar volume; mLAP, mean left atrial pressure; mPAP, mean pulmonary artery pressure; mRAP, mean right atrial pressure; Pao2, arterial oxygen tension; PVR, pulmonary vascular resistance; RV, right ventricular; RVSP, right ventricular systolic pressure; Tlco, transfer factor for carbon monoxide; WHO, World Health Organization.