| Index cases | Non-index cases | p Value | |
| LZDE (%) | 88.55 | 70.89 | <0.001 |
| LZVI–UZVI | 15.52 (0.86) | 8.71 (1.39) | <0.001 |
| Age (years) | 51.74 (0.63) | 48.33 (1.11) | 0.009 |
| Gender (%male) | 64.62 | 53.85 | 0.085 |
| Pack years smoked | 18.00 (7.50–25.50) | 5.25 (0–18.25) | <0.001 |
| FEV1 (% predicted) | 35.41 (1.20) | 75.14 (4.13) | <0.001 |
| KCO (% predicted) | 63.74 (1.41) | 81.15 (2.54) | <0.001 |
LZDE, lower zone dominant emphysema; LZVI–UZVI, lower and upper zone voxel index.